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NEW CRISPRa reagents for gene overexpression! Learn more »
Synthetic & lentiviral reagents for endogenous gene overexpression
Straightforward, efficient tools to study a gene’s function by overexpression in its native context. Our predesigned reagents for human and mouse genes make it easy!
Guaranteed silencing in 3 easy steps
Accell siRNA reagents are guaranteed to silence target gene expression by at least 75% at the mRNA level when used under optimized conditions!
Synthetic sgRNAs for CRISPR-Cas9 gene editing
Synthetic single guide RNAs are easy to design and order through the CRISPR Design Tool!
Ideal for development of therapeutic gene editing applications.
Create a custom library of pre-designed reagents for RNAi, CRISPR, or Over-expression
When Dharmacon pre-defined libraries do not match your experimental requirements, you can make your own custom library with ease, speed and economy.
Online design & ordering tools for precise CRISPR-mediated genome editing
Design custom ssDNA donor oligos.
Generate donor plasmids to insert mKate2, EGFP, or a custom sequence.
CRISPR-Cas9 Gene Editing
Simplify your gene editing workflow with the Edit-R CRISPR-Cas9 platform. Custom or predesigned ready-to-use DNA and synthetic RNA reagents enable you to quickly assess multiple target sites per gene across one or hundreds of genes – moving you closer to high-confidence results.
Custom siRNA screening libraries for ANY species
Enjoy algorithm-designed siRNA produced with a novel enzymatic method to support large functional genomics studies in non-human or mouse models. Whether you only want to screen 1000 key gene targets or a whole genome, we now have a solution for you!
Our RNAi products encompass the most complete portfolio of innovative tools for transient, long-term, inducible and in vivo RNAi applications.
Interrogate gene function through targeted genome editing using powerful molecular tools to permanently alter endogenous gene expression.
cDNAs and ORFs can be used to overexpress particular genes of interest. Choose from individual clones, lentiviral ORFs, and genome-scale libraries.
Use our online design tools and extensive synthesis options to create custom products specific to your application.
A comprehensive portfolio of competitively priced, proven transfection reagents for a wide range of applications.
The safest and most effective strategy for packaging virus to efficiently express your shRNA or gene of interest.
CRISPRa offers you easy-to-use tools that enable gain-of-function genomic studies, and this webinar will show you how to get started!
Learn how Edit-R CRISPRa reagents can induce downstream signaling effects, a useful method for pathway analysis.
Visit the FAQs page for commonly asked questions and to learn what you need to do.