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Vector-based products for studying gene function.
Open Biosystems, which is now a part of GE Healthcare (Dharmacon), began as an entrepreneurial start-up in the Hudson Alpha Institute of Biotechnology offering access to cDNA, ORF and shRNA products through academic partnerships. The Open Biosystems legacy includes vector-based gene modulation reagents that can provide powerful tools to study essential gene function. Choose from a variety of technologies and products functional genomics such as transient, long-term, inducible, and in vivo RNA interference as well as gene over-expression.
Efficient gene silencing with a microRNA-adapted shRNA design. Available as lentiviral vector constructs or high-titer lentiviral particles for human and mouse.
Inducible shRNA expression allows for tightly regulatable RNAi experiments. Available as lentiviral vector constructs for human.
Lentiviral shRNA collection from The RNAi Consortium (TRC). Offers a classic hairpin, rules-based shRNA design with coverage in human and mouse.
Derived from mRNA and including 5' and 3' UTRs, our cDNA collections are ideal for overexpressing a gene in the context of native regulation, while our open reading frames (ORFs) have both 5' and 3' UTRs removed and provide a shortcut to protein expression.
Your complete source for cDNAs, ORFs, knockout strains, promoter collections and other resources for yeast, C. elegans, Zebrafish, Xenopus, and E. coli.
Open Biosystems began as an entrepreneurial start-up in the Hudson Alpha Institute of Biotechnology offering access to cDNA, ORF and shRNA products through academic partnerships. In 2004, the company made available ground-breaking short hairpin RNA (shRNA) libraries developed by Gregory Hannon (Cold Spring Harbor Laboratories) and Steve Elledge (Harvard University) targeting the human and mouse genomes. Published in Nature Genetics in 2005, the Hannon-Elledge libraries were the first genome-scale arrayed shRNA resources modeled after primary microRNA transcripts to be created. Additionally, Open Biosystems entered into an agreement with the Massachusetts Institute of Technology (MIT) in 2005 to serve as a partner of The RNAi Consortium (TRC) and distribute the TRC genome-wide shRNA libraries.
In 2007, Open Biosystems announced the first of several releases of ORFeome Collaboration Clones, sequence-verified human open reading frames (ORFs) drawn from a variety of sources, including principally the Dana Farber Cancer Institute-Center for Cancer Systems Biology. Other contributors to this worldwide collaboration included the Mammalian Gene Collection (MGC) and the IMAGE Consortium.
All of these collections are available as part of the GE Healthcare Dharmacon portfolio.