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The RNAi Global Initiative was founded in 2005 to form a community for interaction and sharing of best-practice for genomewide RNAi screening. Since that time, over 60 member institutes have joined and participated in annual meetings, regular teleconferences, and joint publications. But the question often arises, “What do participating scientists really think of RNAi Global?” At the 2015 annual meeting held in Denver, CO, we put those questions to some of our members. Take a look and hear what they had to say.