Non-targeting siRNAs are designed with three or more mismatches to every lncRNA and protein-coding transcript in human, mouse, and rat.
GAS5 is a widely expressed lncRNA whose knockdown has been demonstrated in multiple cell lines. If GAS5 expression levels are undetermined in your cell type, the use of ON-TARGETplus positive controls is an alternative method for initial experimental optimization.
H=human, M=mouse, R=rat. X=1, 2, 3, or 4