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    Lincode siRNA Libraries

    Choose a collection of Human or Mouse siRNAs based on RefSeq lncRNA genes with NR_ Accession numbers.

    Unbiased RNAi screens have become an important tool for elucidation of novel biological pathways and disease progression. The assessment of potential roles for microRNA and lncRNA, in addition to protein-coding genes, can provide a more complete picture of the genes involved in the phenotype of interest.

    Human and Mouse Lincode siRNA screening libraries are available as SMARTpool or a Set of 4 individual siRNAs to support efforts to decipher lncRNA function.

    Benefits

    • Patented dual-strand modification pattern on all siRNAs to reduce off-targets
    • Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
    • Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
    • Available as SMARTpool siRNA reagents or a Set of 4 siRNAs in 96-well or 384-well plates
    • Human NR lncRNA Library

      3430 total long noncoding RNA gene targets containing at least one NR accession number, includes siRNAs targeting NR transcripts within protein coding genes.

    • Mouse NR lncRNA Library

      1997 total long noncoding RNA gene targets containing at least one NR accession number, includes siRNAs targeting NR transcripts within protein coding genes.

    • Cherry-pick libraries

      Lincode siRNA reagents available as plated libraries for any customer-defined collection of lncRNAs of interest.

    Product Line Selection

    Which siRNA is right for you?

    Dharmacon offers four complete pre-designed product lines across human, mouse and rat genomes. Use the table below to assist you in determining the right siRNA product line for your needs.

    Cost-effective, efficient silencing High specificity for reduced off-targets + efficient silencing Highly specific knockdown of long noncoding RNA (lncRNA) Target silencing in difficult-to-transfect cells
    siGENOME siRNA ON‑TARGETplus siRNA Lincode siRNA Accell siRNA
    Pre-designed for Human, Mouse and Rat protein-coding genes
    Pre-designed for Human and Mouse long noncoding RNA (lncRNA)
    Recommended for transfectable mammalian cells in culture
    Recommended for neuronal, suspension, primary and other difficult-to-transfect cells
    Recommended transfection reagent DharmaFECT transfection reagent DharmaFECT transfection reagent DharmaFECT transfection reagent None required
    Available as SMARTpool reagent
    Available as four individual siRNAs
    Guaranteed knockdown by SMARTpool and 3 of 4 siRNAs
    Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake Selective application when thermodynamic analysis indicates it necessary for favorable antisense RISC loading
    Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
    Modifications to facilitate cellular uptake without separate transfection reagents
    Stabilizing modifications to prevent nuclease-mediated degradation
    Sequence information provided with purchase

    Resources for RNAi Screening Libraries

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