Dharmacon siRNA products are the result of scientific innovation in siRNA design and novel modification strategies to optimize potency, specificity and delivery.
Our scientists were the first to establish siRNA design rules for high potency silencing and continue to drive innovation in this area. The
SMARTselection algorithm selects highly functional and specific siRNAs for all of our predesigned products, enabling us to offer a functionality guarantee for all three of our major product lines:
siGENOME, and Accell reagents.
Pooling of siRNAs better mimics the natural RNAi pathway, and when combined with
SMARTselection design, provides advantages for both potency and specificity.
The primary source of siRNA-mediated off targets is the seed region (nucleotides 2-7) which uses the microRNA pathway to induce non-specific gene silencing via interactions within the 3' UTR. Seed region filters and seed frequency analysis are incorporated in the SMARTselection siRNA design strategy to reduce microRNA-like off-target activity. Dharmacon siRNA products provide the most comprehensive bioinformatic strategies to mitigate off-targeting.
Enjoy optimal specificity from the only siRNA with a patented modification pattern to reduce off-targets caused by either the sense or the antisense strand.
Specially modified for delivery into difficult-to-transfect cells without a transfection reagent, Accell enables non-viral RNAi in neuronal, immune, and stem cells.
Highly potent siRNA for all human, mouse, and rat genes. siGENOME has provided the longest standing siRNA silencing guarantee on the market.
siRNAs for efficient knockdown of long, noncoding RNA (lncRNA) genes with modifications to ensure specificity.
No pre-designed product to fit your needs? Use our online design tools and extensive synthesis options to create a custom siRNA specific for your application.
Validated positive controls and non-targeting negative controls utilizing patented modifications for optimal specificity. Available as pools or single siRNAs.
Effectively optimize Accell siRNA delivery conditions with fluorescent or unlabeled positive and negative controls. Kits of validated controls available.
A robust selection of validated positive, negative, and novel RISC-Free® controls to effectively assess all aspects of RNAi experiments.
Endogenous lncRNA positive control and non-targeting control siRNA and pool reagents for high-confidence experiments.
Find the predefined gene family, including Druggable genes or Whole Genome, that’s right for your discovery efforts.
A wide selection of predefined siRNA libraries, including the most up-to-date Whole Mouse genome collection available.
Human and mouse SMARTpool siRNA libraries in a novel pre-dispensed format to enable RNAi screening without the need for high-throughput automation.
Choose a collection of Human or Mouse siRNAs based on RefSeq lncRNA genes with NR_ Accession numbers.
Paired collections of human siGENOME and ON-TARGETplus siRNA SMARTpool reagents, providing knockdown by the two most reliable siRNA reagents available.
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
Enzymatically generated custom siRNA libraries for screening in non-human or mouse model organisms.
Dharmacon offers four complete pre-designed product lines across human, mouse and rat genomes. Use the table below to assist you in determining the right siRNA product line for your needs.