siGLO Lamin A/C Control siRNA is a validated positive control, guaranteed to silence Lamin A/C in human cells. This control siRNA is chemically modified to significantly extend siRNA stability and fluorescence compared to conventional siRNAs similarly labeled with fluorophores.
Lamins are intermediate filament-type proteins, which form major components of the nuclear lamina. Lamins A and C have close sequence homology and are derived by differential splicing and alternative polyadenylation from one gene. This gene is abundantly expressed in most cells, and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability. Targets accession numbers: NM_005572, NM_170707, NM_170708 (Human), NM_019390 (Mouse), and NM_001002016 (Rat).
Labeled with DY-547 (Cy3 analog) – Absorbance/Emission Max = 557/570 nm
Significantly extended intensity of the fluorescence signal (7 days or longer)
Positive correlation of cytoplasmic fluorescence with transfection efficiency
To request a larger quantity or in vivo
processing of this control product, please email Technical Support
, or call 1-800-235-9880. International customers, please call 303-604-9499 or your local Sales Representative.