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Effective gene silencing by the RNA interference (RNAi) pathway requires a comprehensive understanding of the elements that influence small interfering RNA (siRNA) functionality and specificity. Our scientists were the first to establish siRNA design rules for high potency silencing and continue to drive innovations in this area.
To identify optimal sequences for siRNA targeting, it is necessary to delineate target gene sequence space and build a representative candidate list.
Adapted from A. Birmingham et. al., A protocol for designing siRNAs with high functionality and specificity, Nature Methods., Aug 2007; 9: 2068-2078